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尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )，uPA是一種絲氨酸蛋白水解酶。小鼠uPA基因位于第10條染色體長(zhǎng)臂上，其長(zhǎng)度為6.5KD，由11個(gè)外顯子構(gòu)成，可轉(zhuǎn)錄成24KB的成熟的mRNA，初始翻譯產(chǎn)物為前尿激酶原（含431個(gè)氨基酸殘基），除去20個(gè)氨基酸殘基的信號(hào)肽后即為細(xì)胞分泌的尿激酶原（pro-uPA），在158LYs位處劈裂，則成為由二硫鍵連結(jié)的雙鏈活性型結(jié)構(gòu)，即20×103的A鏈和34×103的B鏈。C端的A鏈包括一個(gè)Kringle區(qū)和表皮生長(zhǎng)因子（EGF）功能區(qū)，表皮生長(zhǎng)因子功能區(qū)能介導(dǎo)與特異的受體結(jié)合，去掉此功能區(qū)，其仍具有激活纖溶酶原作用，,但卻無(wú)與受體結(jié)合的能力。C端的B鏈有絲氨酸蛋白酶功能區(qū)，為uPA的活性中心。uPA的合成與分泌受諸多因素影響，如原癌基因V-Src、Ras、細(xì)胞因子TNF、INF、IL-1、TGF-β、IGF-1、FGF、基質(zhì)金屬蛋白酶等。一般說(shuō)來(lái)，uPA主要在生理、病理?xiàng)l件下與細(xì)胞分化、遷移、組織重建、細(xì)胞周?chē)|(zhì)降解有關(guān)。
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )，蛋白
| 貨號(hào) | 品名 | 包裝 | 價(jià)格 | 品牌 |
| ADG108 | Urokinase-Receptor (uPAR), human, rec | 200 µg | 9725 | American Diagnostica Inc |
| 107 | urokinase, human, single-chain (scuPA), frozen solution, dry-ice shipment | 25 µg | 6900 | American Diagnostica Inc |
| ADG146NL | urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment | 1 mg | 86375 | American Diagnostica Inc |
| ADG146N | urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment | 0.1 mg | 15500 | American Diagnostica Inc |
| EZ005C | Urokinase type Plasminogen Activator (uPA) | 1 x 100,000 units | 4710 | hyphen biomed |
| EZ005B | Urokinase type Plasminogen Activator (uPA) | 1 x 10,000 units | 1035 | hyphen biomed |
| EZ00 | Urokinase type Plasminogen Activator (uPA) | 1 x 1,000 units | 465 | hyphen biomed |
| ADG125N | Urokinase (uPA), human, recombinant, LMW, frozen solution, dry-ice shipment | 100 µg | 9725 | American Diagnostica Inc |
| ADG102 | Urokinase (uPA), human, HMW | 250,000 IU | 詢(xún)價(jià) | American Diagnostica Inc |
| ADG100 | Urokinase (uPA), human, HMW | 10,000 IU | 5000 | American Diagnostica Inc |
| 128 | urokinase (uPA), human, HMW | 100,000 IU | 13452 | American Diagnostica Inc |
| ADG244FN | SPECTROFLUOR® uPA | 10 µmole | 1850 | American Diagnostica Inc |
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )抗體
| 貨號(hào) | 品名 | 包裝 | 價(jià)格 | 品牌 |
| 11651-05021 | Urokinase (uPA), anti-human | 150 ug | 2800 | AssayPro |
| 11651-05011 | Urokinase (uPA), anti-human | 150 ug | 2320 | AssayPro |
| 12172-05021 | uPA, anti-rat | 150 ug | 2800 | AssayPro |
| 12172-05011 | uPA, anti-rat | 150 ug | 2320 | AssayPro |
| TC42000 | u-PA purified protein, lyo. 125 µg | RUO | 3941.28 | Technoclone |
| TC31014 | Polyclonal anti u-PA antibody (rabbit)1 mg | RUO | 2650.98 | Technoclone |
| TC31015 | Polyclonal anti u-PA antibody (rabbit) 5 mg | RUO | 4128.96 | Technoclone |
| ADG3471 | murine MAb against uPA-ATF (aa 17-34) | 250 µg | 3950 | American Diagnostica Inc |
| ADG3689 | murine MAb against uPA b-chain, affinity purified | 250 µg | 4475 | American Diagnostica Inc |
| TC21063 | Monoclonal anti u-PA antibody 4UK | RUO | 4715.46 | Technoclone |
| 12171-05021 | ATF-uPA, anti-mouse | 150 ug | 2800 | AssayPro |
| 12171-05011 | ATF-uPA, anti-mouse | 150 ug | 2320 | AssayPro |
| 11661-05021 | ATF uPA, anti-human | 150 ug | 2800 | AssayPro |
| 11661-05011 | ATF uPA, anti-human | 150 ug | 2320 | AssayPro |
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )試劑盒
| 貨號(hào) | 品名 | 包裝 | 價(jià)格 | 品牌 |
| RK018A | ZYMUTEST uPA-PAI-1 complexes | Kit of 96 tests | 7800 | hyphen biomed |
| RK013A | ZYMUTEST uPA Antigen | Kit of 96 tests | 7290 | hyphen biomed |
| TC12010 | u-PA ELISA Kit 96 T. | RUO | 9196.32 | Technoclone |
| TC16010 | u-PA Combi Actibind ELISA Kit 96 T. | RUO | 10603.92 | Technoclone |
| 894 | IMUBIND® uPA ELISA | 96 microwell plate | 10704 | American Diagnostica Inc |
| EU1001-1 | Human Urokinase (uPA) ELISA Kit | 96 well plate | 4760 | AssayPro |
| CU1001b | Human Urokinase (uPA) Chromogenic Activity Assay Kit (Indirect Assay) | 96 well plate | 6930 | AssayPro |
| CU1001a | Human Urokinase (uPA) Chromogenic Activity Assay Kit (Direct Assay) | 96 well plate | 5530 | AssayPro |
| 899 | FEMLE™ uPA/PAI-1 ELISA, - CE | 2x96 microwell plates | 詢(xún)價(jià) | American Diagnostica Inc |
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